Jesko was a graduate student in the lab, which he joined in 2006. His studies
focused on the
Neurexin and Neuroligin synaptic cell adhesion protein families. Both protein families undergo
extensive alternative splicing. He was particularly interested in investigating a proposed
Neurexin/Neuroligin “affinity regulation hypothesis” for NRXs and NLs which suggests that
alternative splicing of either binding partner regulates the affinity of their interaction, and that this is
important to recognition between synaptically connected neurons with biophysical and structural techniques.